Drs. Baldwin and Harper share clinical updates on the management of acne and rosacea, highlighting evolving treatment strategies and emerging therapies. Dr. Harper discusses a shift toward initiating treatment for moderate-to-severe acne with topical therapies before adding oral antibiotics when needed, emphasizing the importance of antibiotic stewardship, and reviews investigational approaches including fatty acid synthase inhibitors as well as vaccines designed to reduce inflammation and prevent acne scarring. Dr. Baldwin provides practical insights into rosacea management, reviewing evidence supporting low-dose, extended-release minocycline, the anti-inflammatory role of tetracyclines, and very low-dose isotretinoin, finishing with a discussion of the challenges of managing neurogenic and ocular rosacea.