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Jennifer Hsiao, MD: Off-Label Approaches for Recalcitrant Hidradenitis Suppurativa

Dr. Hsiao reviews practical off-label strategies for patients with recalcitrant hidradenitis suppurativa whose disease remains active despite standard treatment. She emphasizes individualized, multimodal care that combines foundational therapies with adjunctive agents, therapeutic drug monitoring, and, in select cases, dual immunomodulatory treatment.

Topics Covered

  • Building multimodal treatment plans for difficult-to-treat hidradenitis suppurativa
  • Combining biologics or small-molecule inhibitors with topical or metabolic therapies
  • Using biologic trough levels and anti-drug antibody testing to optimize response
  • Considering dual immunomodulatory therapy in carefully selected patients
  • Tailoring treatment-stacking strategies to persistent disease activity

 

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