Dr. Blauvelt highlights the clinical significance of aiming for 100% skin clearance in patients with psoriasis. He explains that quality of life studies show a precipitous drop in patient well-being when even a single psoriasis plaque remains, as it serves as a daily reminder of the chronic disease. He highlights that achieving absolute clearance also mitigates severe comorbidities, lowering a patient’s risk for psoriatic arthritis and heart disease. Ultimately, he encouraged clinicians to utilize the most effective IL-17 and IL-23 blockers early in the disease duration.
