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Diego Ruiz Dasilva, MD: IL-36 Receptor Inhibition for GPP Treatment

Dr. Dasilva discusses the evolving management of generalized pustular psoriasis (GPP), highlighting the impact of targeted interleukin (IL)-36 receptor inhibition for this potentially life-threatening disease. He notes the limitations of off-label therapies, including advanced systemic psoriasis treatments, cyclosporine, and corticosteroids, and explains how IL-36 pathway inhibition offers a disease-specific approach for both rapid flare control with intravenous induction and long-term maintenance with subcutaneous therapy. Dr. Dasilva also highlights emerging research evaluating IL-36 inhibition in other neutrophilic dermatoses, including pyoderma gangrenosum, and discusses the potential implications for future clinical practice.

Topics Covered:

  • IL-36 receptor inhibition for acute and maintenance treatment of GPP
  • Limitations of traditional therapies and evolving treatment strategies
  • Emerging applications for IL-36 inhibition in neutrophilic dermatoses

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Leonardo Tjahjono, MD, FAAD: Efficacy of Spesolimab With Variable Dosing in GPP

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Boni Elewski, MD, a professor and chair of dermatology at the University of Alabama in Birmingham, Alabama, discusses the characteristics and diagnosis of generalized pustular

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Johann E. Gudjonsson, MD, PhD: Mitigating Low-grade Inflammatory Activity in Generalized Pustular Psoriasis

Dr. Johann Gudjonsson discusses how spesolimab may reduce low-grade inflammation between flares in patients with generalized pustular psoriasis (GPP). Topics Covered: Subclinical inflammation in GPP

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Tina Bhutani, MD: Raising Awareness for Generalized Pustular Psoriasis

Dr. Tina Bhutani highlights the National Psoriasis Foundation’s efforts to raise awareness for generalized pustular psoriasis and support affected patients. Topics Covered: GPP awareness initiatives

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Tina Bhutani, MD: Reviewing the Pathogenesis of Generalized Pustular Psoriasis

Dr. Bhutani reviews the underlying disease mechanisms of Generalized Pustular Psoriasis (GPP), focusing on the role of inflammatory signaling pathways that drive the condition. Her

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Tina Bhutani, MD: Assessing the Quality of Life Impact in Patients with Generalized Pustular Psoriasis

Dr. Bhutani examines the significant quality-of-life burden associated with Generalized Pustular Psoriasis (GPP), a rare and severe inflammatory skin condition. Her discussion highlights how frequent

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Tina Bhutani, MD: Diagnosing Patients with Generalized Pustular Psoriasis

Dr. Bhutani discusses the diagnostic challenges associated with Generalized Pustular Psoriasis (GPP), a rare and often unpredictable inflammatory skin disease. Her presentation highlights the importance

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