Stephanie DePouw-Simmerman, DNP, APRN: Overview and Long-Term Safety Profile of Ruxolitinib for Vitiligo

October 20, 2026

Stephanie DePouw-Simmerman, DNP, APRN, outlines the 2-year safety data for ruxolitinib in vitiligo treatment, noting that common side effects like nasopharyngitis, upper respiratory infections, and headaches are manageable. She explains that historical treatment options relied on short-term steroid use, which carries risks of metabolic side effects, bone health issues, and skin striae. Topical ruxolitinib offers a favorable alternative due to its low systemic absorption and well-tolerated profile. Providers are advised to set clear patient expectations regarding safety, ongoing infection monitoring, and the patience required for vitiligo repigmentation.

Topics Covered:

2-year safety data and low adverse event rates
Limitations and side effects of historical steroid treatments
Setting patient expectations and managing repigmentation timelines

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