Julien Seneschal, MD, PhD: Immune Pathogenesis of Vitiligo

Drawing from his presentation at the AAD 2025 Annual Meeting, Dr. Seneschal reviews the immune mechanisms underlying Vitiligo and explains why long-term maintenance therapy is often necessary to sustain repigmentation and reduce the risk of disease recurrence.

His discussion explores how ongoing immune activity contributes to melanocyte destruction and why continued treatment may be needed even after successful repigmentation.

Topics Covered

The immune pathogenesis of vitiligo
How autoimmune processes target melanocytes
Why vitiligo often requires long-term maintenance therapy
The relationship between disease mechanisms and treatment strategies
Clinical implications for preventing relapse after repigmentation

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