Welcome to the August 2017 edition of The Journal of Clinical and Aesthetic Dermatology. We start the issue with a review article by Cheraghi et al that explores and discusses the various types of radiation therapy for keloids. Based on the literature, the authors report that keloids treated with postexcisional radiation therapy can achieve excellent results with minimal complications or recurrences.
Following this, Chao et al present the results of their consensus panel that examined differences in aesthetic preferences between Asian and Caucasian patients and appropriate treatment methods based on these preferences. The overall consensus was that although treatments and treatment sequences for early intervention/enhancement and restoration for beautification in Asian patients are similar to those in Caucasian patients, different treatment strategies may be required based on differences in aesthetic preferences. The authors describe the consensus recommendations on aesthetic interventions and combination treatment algorithms for Asian patients, with a particular focus on the application of botulinum toxin A (BoNT-A), injectable fillers, and microfocused ultrasound with visualization (MFU-V).
Next, Tian presents a brief report that examines the use of a fractional 2940nm nonablative Erb:YAG micropeel laser for treatment of freckles among five Chinese patients with Skin Types III/IV. The author reports that the freckles cleared greater than 90 percent following one treatment.
Following this, in their prospective, pilot clinical trial, Wu and colleagues explore whether a lower dose of ingenol mebutate gel 0.015% could clear actinic keratosis on the chest with acceptable tolerability. The investigators conclude that ingenol mebutate gel 0.015%, applied to less than 100cm2 area of the chest once daily for three consecutive days, reduced the actinic keratosis count and significantly improved signs of photoaging, with high patient satisfaction and good tolerability.
Next, in a brief report by Roberts and colleagues, the authors examine the efficacy of a topical product containing urea, lipids, sodium copper chlorophyllin complex, antioxidants, and humectants in subjects with moderate-to-severe photodamage of the hands. While the results are preliminary, the authors report that global improvement (which was based on a combination of photographic assessment and visual clinical evaluation) was rated as moderate improvement for all eight subjects.
Following this, Cohen and Jiang describe a case of a man with cutaneous squamous cell carcinoma (SCC) of the distal pad of his left fourth finger. The authors describe treatment, features, and differential diagnoses associated with SCC of the ventral finger.
Next, Endly and Miller review numerous topical treatment options for oily skin, including retinoids, olumacostat glasaretil, and various cosmeceutical agents. They also describe several systemic and procedural techniques that incorporate isotretinoin, spironolactone, oral contraceptives, botulinum toxin, photodynamic therapy, and lasers. The authors analyze each treatment option in terms of the proposed mechanism of action, efficacy reported in the literature, and potential adverse effects.
And finally, in their prospective clinical trial, Esperíto-Santo et al evaluate the use of the 1340nm laser as a monotherapy for toenails affected by onychomycosis. Considering three applications of laser therapy and a clinical/laboratory follow-up period of 12 weeks, the authors report that monotherapy with 1340nm laser was not effective.
We hope you enjoy the issue. As always, we welcome your comments and submissions.
James Q. Del Rosso, DO, FAOCD
Editor-in-Chief, Clinical Dermatology
Wm. Philip Werschler, MD, FAAD, FAACS
Editor-in-Chief, Aesthetic Dermatology
Seemal R. Desai, MD, FAAD