J Clin Aesthet Dermatol. 2023;16(3):44–50.
by Indrashis Podder, MD; Arunima Dhabal, MD; and Sankha Subhra Chakraborty, MBBS
All authors are with the College of Medicine and Sagore Dutta Hospital, in Kolkata, West Bengal India.
FUNDING: No funding was provided for this article
DISCLOSURES: The authors report no conflicts on interest relevant to the content of this article.
Abstract. Background. Oral second-generation antihistamines (sgAH) constitute the first-line treatment for chronic spontaneous urticaria (CSU), a debilitating dermatological condition. However, many patients respond incompletely, and up-dosing sgAHs up to four-fold their conventional dose is recommended for disease control. Many physicians refrain from up-dosing due to a paucity of efficacy and safety data, instead adding a second antihistamine or an immunomodulator.
Objective. With the aim of addressing this knowledge gap, we conducted a literature review to highlight efficacy and safety data on up-dosed sgAHs.
Methods. We conducted a comprehensive search of the literature across multiple databases (PubMed, EMBASE, MEDLINE and Google scholar) using the keywords (alone and in combination) and MeSH items as well as non-MeSH terms such as “chronic spontaneous urticaria”, “chronic idiopathic urticaria”, AND “updosing”, “second-generation anti-histamines”, “cetirizine”, “fexofenadine”, “levocetirizine”, “desloratadine”, “ebastine”, “bilastine”, and “rupatadine”.
Results. Our review suggests bilastine, fexofenadine, levocetirizine, and cetirizine are recommended for up-dosing in non-responsive patients with CSU (Grade A recommendation), while desloratadine and ebastine can be recommended (Grade B recommendation). Among those with Grade A recommendation, bilastine and levocetirizine may be up-dosed safely to four times, while fexofenadine has been studied at three times the conventional dose. None of the drugs showed any dose-dependent increase of adverse effects; however, cetirizine up-dosing may increase the risk of dose-related sedation. There were no reports of systemic complications, including cardiotoxicity, at higher than licensed doses of these drugs. Only cetirizine and rupatadine up-dosing have been documented to be effective and safe in children, while there is lack of data on geriatric patients and pregnant or lactating females.
KEYWORDS: Chronic spontaneous urticaria, second generation anti-histamines, up-dosing, effectiveness, safety
Chronic urticaria (CU) is a dermatological condition characterized by recurrent transient wheals, with or without angioedema, occurring daily or almost daily for more than six weeks.1 There are two variants—chronic inducible urticaria (CIndU) or physical urticaria, which is triggered by certain physical stimuli like pressure, heat, or cold, and the more common chronic spontaneous urticaria (CSU), which develops without any known exogenous stimulus and accounts for 80 to 90 percent of cases.2 This disease affects 0.5 to 1 percent of the global population, with female preponderance.3 The recurrent symptoms often result in sleep disturbances and cause notable negative impacts on quality of life (QoL).4
Although the exact pathogenesis remains unclear, CSU is a mast cell-driven disease involving histamine as the predominant mediator. Thus, antihistamines form the first-line treatment for this condition, and second-generation antihistamines (sgAH) are recommended due to their minimal anti-cholinergic, sedative, and drug-interacting properties and longer half-lives.1 However, almost 60 percent of patients remain uncontrolled with the standard licensed dose of sgAHs (Table 1).3,5 In this subset of patients, up-dosing of sgAHs up to four times the licensed dose has been recommended by most guidelines, allowing 2 to 4 weeks for response at each dose.1,6 Nevertheless, this recommendation is primarily based on expert opinions, and several studies concerning sgAH up-dosing have shown conflicting results. Additionally, the safety profile of up-dosed sgAHs needs to be considered carefully, as two of the earliest marketed sgAHs, astemizole and terfenadine, have been withdrawn because of their potential cardiotoxicity.7
The present article aims to review the effectiveness and safety of up-dosed sgAHs in an evidence-based manner, to promote their use in a more rational manner.
We conducted a comprehensive search of literature concerning up-dosing of second generation anti-histamines (sgAHs) across multiple databases (PubMed, EMBASE, MEDLINE and Google scholar) using the keywords (alone and in combination) and MeSH items as well as non-MeSH terms, such as “chronic spontaneous urticaria”, “chronic idiopathic urticaria”, AND “updosing”, “second-generation anti-histamines”, “cetirizine”, “fexofenadine”, “levocetirizine”, “desloratadine”, “ebastine”, “bilastine”, “rupatadine”. We included all types of articles, but excluded articles not published in the English language. The references of relevant articles were further scanned for more articles.
The obtained articles were evaluated using two systems—“Oxford Centre for Evidence-Based Medicine (OCEBM)” AND “strength of recommendation taxonomy” (SORT). Oxford Centre for Evidence-Based Medicine (OCEBM) is based on an evidence-based approach for treatment benefit regarding the study quality, their imprecision and indirectness and categorized into the following: Level 1 (systematic review of randomized trials or n-of-1 trials); Level 2 (randomized trial or observational study with dramatic effect); Level 3 (non-randomized controlled cohort/follow-up study); Level 4 (case-series, case-control studies, or historically controlled studies); and Level 5 (mechanism-based reasoning).8 The evidence in SORT, developed by editors of the United States Family Medicine and Primary Care journals (i.e., American Family Physician, Family Medicine, Journal of Family Practice and British Medical Journal USA) was graded using a three-point scale based on the quality of methodology, as follows: Level I=Good-quality, patient-oriented evidence; Level II=Limited-quality patient-oriented evidence; Level III=Other evidence, including consensus guidelines, opinion or case studies.9 Clinical grade of recommendations were developed on the best available evidence and graded as follows: A=Recommendation based on consistent Level 1 evidence; B= Recommendation based on consistent Level 2 or 3 studies, or extrapolation from Level I studies; C=Recommendation based on Level 4 studies or extrapolation from Level II or III studies; and D=Level 5 evidence or inconsistent and inconclusive studies at any level.8 For clinical implication, based on consensus, the grades of recommendation may be considered as: Grade A=is recommended; Grade B=can be recommended; Grade C=may be recommended; and Grade D=may be considered.
Several studies have been conducted to assess the utility and safety of sgAHs, when administered at higher than conventional dose with variable outcomes. Studies concerning individual drugs have been briefly mentioned below, along with their levels of recommendation (Table 2).3,10–21
Cetirizine. Cetirizine is one of the oldest sgAHs to be used for the treatment of CU. Kameyoshi et al10 demonstrated more effective symptomatic control with doubled dose of cetirizine (20mg daily) in uncontrolled patients, compared to standard dose (10 mg daily). However, another study reported clinical improvement in only five percent of refractory patients when cetirizine dose was increased by three times (30mg daily). The authors recommended treatment with steroids and immunosuppressants in such patients for effective disease control.11 A meta-analysis and a recent systematic review have also detected increased effectiveness on up-dosing of cetirizine (Table 2).3,12
There are variable reports regarding adverse effects of increased doses of cetirizine. Kameyoshi et al10 reported increased sedation in 10 percent of patients on up-dosing (20mg daily), while Asero11 reported increased tiredness and somnolence in 59% patients (30mg daily). No other systemic adverse effects were reported by either authors. Notably, higher dose of cetirizine (up to 3-times up-dosing or 30mg daily) has been found to be remarkably safe from a cardiovascular point of view, as it remains inactive on hERG channels, inhibition of which is responsible for antihistamine-related cardiotoxicity.7
Up-dosing of cetirizine has a Grade A recommendation and is recommended in uncontrolled CSU. However, evidence is limited, as studies show conflicting results and there is increased risk of sedation at higher dose (Table 2).
Fexofenadine. There are inconsistent results regarding up-dosing of fexofenadine. Magen et al. observed no significant clinical improvement in 31 percent of patients, even when fexofenadine dose was escalated to four times the conventional dose (720 mg daily). However, four-fold increased dose significantly reduced autologous serum-induced wheal size compared to standard dose.14 In contrast, several authors have reported significant clinical improvement in uncontrolled patients when the dose was increased to 240mg, 360mg and 540mg daily at intervals of 1 to 2 weeks.13,15 A meta-analysis also found fexofenadine up-dosing to be effective in 83.07 percent (95% CI 68.14-99.45) of non-responsive patients with CSU, the highest rate among all sgAHs.12 This view is further corroborated by a recent systematic review which found two-fold up-dosing of fexofenadine to be effective in uncontrolled patients (Table 2).3
Fexofenadine has shown safety, even in increased doses (up to 540mg daily, or 3-times standard dose). The most common adverse effects with high doses are headache, followed by sedation, but no dose-dependent exacerbation has been reported. Concerning systemic side effects, no psychomotor or cognitive disruption has been reported at 360mg daily, as there is minimal transfer across the blood-brain barrier, while cardiac safety, including QT interval, has been maintained at even higher doses (800mg once daily to 690mg twice daily).7,22
Up-dosing of fexofenadine is recommended in uncontrolled patients with CSU at licensed dose, as there is Grade A recommendation. Dose may be escalated to three times the licensed dose (540mg daily) safely, without any significant dose-dependent increase of adverse effects (Table 2).
Levocetirizine. Several authors have reported increased clinical improvement and QoL with up-dosed levocetirizine (up to 4 times or 20mg daily), when administered sequentially to uncontrolled patients on standard dose, although the inter-group difference was not significant.16-18 Notably, Sharma et al18 reported no significant improvement in almost 30 percent of patients, even on four-fold up-dosing.18 Furthermore, levocetirizine has been found to be more effective (p<0.05) compared to desloratadine, when both are escalated to four times their standard dose (20mg daily).17 A meta-analysis and a recent systematic review have also detected increased effectiveness on up-dosing of levocetirizine.3,12
In all studies, sedative effects with increased doses of levocetirizine were mild and affected only a small percentage of the subjects. Sharma et al18 found that more than 75 percent of the patients who experienced somnolence developed it on the standard 5mg dose, suggesting that up-dosing marginally increases the risk of sedation.18 Staevska et al17 reported no change/reduced sedation in 75 percent of subjects, possibly attributable to improved sleep-quality and daytime wakefulness and tolerance to the sedative property of drug.17 Cardiac safety has been demonstrated with up to six-fold the standard dose without any QT-interval polongation or arrhythmia.7
There is Grade A recommendation and levocetirizine is recommended for up-dosing in refractory CSU. It may be safely up-dosed to guideline-recommended four times the standard dose (20mg daily) without any notable adverse effect. However, almost one third of patients may remain unresponsive to up-dosed levocetirizine.
Desloratadine. A single study has shown comparable rates of improvement of CSU when desloratadine was sequentially increased from 5mg to 20mg daily. However, 70 percent remained unresponsive to 20-mg dose. Twenty-five percent of the non-responders became asymptomatic with 20mg levocetirizine; on the contrary, none of the levocetirizine non-responders improved with 20mg of desloratadine. Overall, the authors found levocetirizine to be statistically superior to desloratadine in improving symptoms and quality of life.17 Notably, Siebenhaar et al23 have reported desloratadine 20mg to be more effective than the standard dose (5mg daily) in acquired cold urticaria (ACU), a type of CInDU.23
Neither study has reported any significant adverse effects with increased dose (up to 4-fold), without any evidence of dose-related increased somnolence.17,23 Additionally, no significant risk of cardiac arrhythmias has been observed with up to four times the standard dose of desloratadine.7
Desloratadine has limited evidence regarding its up-dosing in uncontrolled CSU, although there is Grade B recommendation (based on a single study) and can be recommended. Although updosing is safe, a large proportion of patients may remain unresponsive. Such patients may be given an alternate antihistamine, such as levocetirizine or immune-modulators.
Ebastine. A single study (n=30) has demonstrated the effectiveness of sequentially up-dosed ebastine in unresponsive CSU patients starting from 10mg (standard dose) to 40mg (4-times up-dosing), over four weeks. They reported 20mg to be more effective than 10mg, and two patients who remained symptomatic with 20mg, improved with 40mg dose.19
The author reported no significant adverse effect with increased doses; only mild sedation was reported by one patient at the maximal dose of 40 mg.19 Additionally, in-vivo studies have confirmed good cardiovascular tolerability without any QT prolongation, even when the dose is increased by five times.24
Ebastine can be recommended for up-dosing in uncontrolled CSU (Grade B recommendation; single study), although there is limited evidence. There is no risk of significant ADRs at higher dose.
Bilastine. Bilastine is a relatively new long-acting, sgAH, recently approved for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria. It does not cross the blood brain barrier and is free of any sedative effect (non-sedative), apart from being devoid of any systemic adverse effects or drug interactions.
A randomized dose-ranging trial studied bilastine in doses of 10, 20, and 30 mg versus placebo to assess disease control in CSU based on the number of wheals and itching. All doses were statistically better than placebo, however no significant difference was observed between the doses, despite showing a dose-related trend.20 Weller et al21 may be credited to perform the first authentic up-dosing study with bilastine in patients with uncontrolled CSU at licensed doses of other sgAHs such as loratadine, cetirizine, rupatadine, ebastine, fexofenadine anddesloratadine. They administered bilastine in gradually escalating doses (20, 40 and 80mg daily) at two-week intervals, to patients not responding to the preceding lower dose (UAS7>3). They concluded that licensed dose of bilastine is effective in moderate to severe CSU patients not responding sufficiently to other sgAHs, and there is definite benefit of up-dosing to double or four times the licensed dose in terms of reduction in mean UAS7.21 A recent systematic review has also found increased effectiveness for up-dosed bilastine.3 In addition to CSU, up-dosing to four times the dose has also been found to be effective and safe in cold contact urticaria.25
Bilastine is a safe antihistamine without any sedative effects or cognitive impairment, and this property is maintained even on up-dosing up to four times the licensed dose.21,25,26 No systemic adverse effects, including cardiac complications, have been reported even with doses up to five times the licensed dose.7,27
Bilastine has Grade A recommendation and is recommended for up-dosing in uncontrolled CSU. It may be up-dosed safely to four times its licensed dose without any sedation or cognitive impairment.
Rupatadine. Rupatadine is a sgAH with a higher receptor affinity than levocetirizine and fexofenadine, along with additional anti-platelet activating factor (PAF) effects.28 PAF is a recognized mediator in CSU, and rupatadine was proposed to be a significant addition to the existing array of antihistamines.29
To the best of our knowledge, there are no studies on rupatadine up-dosing in uncontrolled CSU. Studies have been conducted to determine its dose in naïve patients with CSU, with conflicting results. Dubertret et al30 observed faster and longer-lasting symptomatic relief with rupatadine 10 and 20 mg; however, a clear dose-response was observed for 20-mg dose.30 Contrarily, Giménez-Arnau et al31 observed no significant difference between the two doses (10 or 20 mg daily) with respect to pruritus severity, number of wheals, and total symptoms scores.31 However, in a pooled data analysis including both trials (n=538), 20 mg daily resulted in a higher proportion of patients with a 75-percent or greater response for all three parameters assessed (Mean Pruritus Score, Mean Number of Wheals, and Mean UAS) than 10-mg dose.32 Thus, in CSU the maximum studied dose remains 20mg daily, although up-dosing up to four times (40mg daily) is supported in cold urticaria with better response than 20mg daily dose.33 Recently, a post-hoc analysis of a Phase III clinical trial has indicated increased efficacy of up-dosed rupatadine (up to 20mg) in Japanese patients with CSU, dermatitis, or pruritus.34 However, this study included patients without exclusive CSU, and there was no definite criteria or timing for up-dosing (patients simply up-dosed during the earlier Phase III study due to lack of efficacy, or later due to aggravation of symptoms), and thus not considered while generating evidence for the current review.
A dose-related increase in adverse effects was reported in both trials, with somnolence and headache being most frequent. Rupatadine 10mg was tolerated better than 20mg; however, the differences between the incidence or type of adverse effects noted with the two doses were not significant.30,31 The cardiac safety of rupatadine has been studied and no significant changes in cardiac repolarization were noted with doses up to tenfold higher than the recommended dose.7
Currently, rupatadine has no evidence for up-dosing in uncontrolled CSU. However, based on previous studies, two-fold up-dosing (20mg) may be attempted in unresponsive patients, taking into account the increased risk of somnolence and headache in a dose-dependent manner.
Up-dosing in special populations. Until recently, there was no literature concerning up-dosing of antihistamines for treating CSU in special populations, such as pediatric and geriatric age groups, and pregnancy or lactating patients. However, recently, Gabrielli et al35 and Sarita et al36 documented the effectiveness and safety of up-dosed second generation antihistamines in children. Gabrielli et al demonstrated only 10 percent of children to be unresponsive to maximally updosed sgAHs (up to four times), compared to 50 percent of adults, and they attributed this discrepancy to varying pathogenic mechanisms. Sarita et al36 found up-dosed cetirizine and rupatadine (up to four times standard dose) to be tolerable and safe in children with refractory CSU, however efficacy appeared to be limited to double the standard dose. To the best of our knowledge, there is no data yet concerning geriatric patients and pregnant or lactating patients. The authors recommend up-dosing of cetirizine and rupatadine in children with CSU not responding to standard does as per current guidelines, however the same cannot be extrapolated to elderly, pregnant and lactating patients due to a dearth of quality evidence.
Although several studies have been conducted concerning the up-dosing of sgAHs in uncontrolled CSU, the results are not uniform for all drugs. Bilastine, fexofenadine, levocetirizine and cetirizine have grade A recommendation for up-dosing, while desloratadine and ebastine have Grade B recommendation. Up-dosing possibly exerts a significant impact on pruritus, but not on wheal number.12 Besides urticaria control, these drugs also improve the QoL and sleep quality of affected individuals. Bilastine and levocetirizine may be safely up-dosed to four times their licensed dose, consistent with guidelines, while fexofenadine has been safely up-dosed to three-fold. Cetirizine up-dosing may result in increased dose-dependent sedation, while a considerable proportion of patients may respond inadequately to higher doses of levocetirizine and desloratadine. No drug is associated with systemic complications including cardiotoxicity, even at higher doses. No statistical difference has been noted regarding occurrence of unwanted effects and sedation with standard or higher dose. However, patients tend to have a negative perception towards up-dosing of sgAHs being concerned about their long-term harmful effects, loss of effectiveness and dependence.37 Cetirizine and rupatadine may be considered for up-dosing in children, while increasing the dose is not yet recommended in elderly, pregnant, or lactating patients. Thus, adequate counseling is necessary to motivate these patients for up-dosing if they remain uncontrolled at standard doses. We also noted considerable heterogeneity in the evidence with respect to study designs, sample-size, study duration and interval between dose-escalations. Further large-scale and well-designed trials adhering to the current treatment guidelines are necessary to validate or refute our evidence-based recommendations.
- Zuberbier T, Aberer W, Asero R, et al. The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73:1393–1414.
- Saini SS, Kaplan AP. Chronic spontaneous urticaria: the devil’s itch. J Allergy ClinImmunol Pract. 2018;6:1097–1106.
- IriarteSotés P, Armisén M, Usero-Bárcena T, et al. Up-Dosing Antihistamines in Chronic Spontaneous Urticaria: Efficacy and Safety. A Systematic Review of the Literature. J InvestigAllergol Clin Immunol. 2020 Oct 8 [Ahead of print].
- Godse K, Bhattar P, Patil S, et al. Updosing of Nonsedating Anti-histamines in Recalcitrant Chronic Urticaria. Indian J Dermatol. 2016;61:273–278.
- Maurer M, Costa C, Gimenez Arnau A, et al. Antihistamine-resistant chronic spontaneous urticaria remains undertreated: 2-year data from the AWARE study. Clin Exp Allergy. 2020 50:1166–1175.
- Godse K, De A, Zawar V, et al. Consensus statement for the diagnosis and treatment of urticaria: A 2017 update. Indian J Dermatol. 2018;63:2–15.
- Cataldi M, Maurer M, Taglialatela M, et al. Cardiac safety of second-generation H1-antihistamines when updosed in chronic spontaneousurticaria. Clin Exp Allergy. 2019;49:1–9.
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- Ebell MH, Siwek J, Weiss BD, et al. Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature. Am Fam Physician. 2004;69:548–556.
- Kameyoshi Y, Tanaka T, Mihara S, et al. Increasing the dose of cetirizine may lead to better control ofchronic idiopathic urticaria: An open study of 21 patients. Br J Dermatol. 2007;157:803–804.
- Asero R. Chronic unremitting urticaria: Is the use of antihistamines above the licensed dose effective? A preliminary study of cetirizine at licensed and above-licensed doses. Clin Exp Dermatol. 2007;32:34–38.
- Guillén-Aguinaga S, Jáuregui Presa I, Aguinaga-Ontoso E, et al. Updosing nonsedating antihistamines in patients with chronic spontaneous urticaria: a systematic review and meta-analysis. Br J Dermatol. 2016;175:1153–1165.
- Godse KV, Nadkarni NJ, Jani G, et al. Fexofenadine in higher doses in chronic spontaneous urticaria. Indian Dermatol Online J. 2010;1:45–46.
- Magen E, Mishal J, Zeldin Y, et al. Antihistamines do not inhibit the wheal induced by the intradermal injection of autologous serum in resistant chronic idiopathic urticaria. Allergy Asthma Proc. 2012;33:531–537.
- Tanizaki H, Nakahigashi K, Miyachi Y, et al. Comparison of the efficacy of fexofenadine 120 mg and 240 mg per day on chronic idiopathic urticaria and histamine-induced skin responses in Japanese populations. J Dermatolg Treat. 2013;24:477–480.
- Godse KV. Updosing of antihistamines to improve control of chronicurticaria. Indian J Dermatol VenereolLeprol. 2010;76:61–62.
- Staevska M, Popov TA, Kralimarkova T, et al. The effectivenessof levocetirizine and desloratadine in up to 4 timesconventional doses in difficult-to-treat urticaria. J Allergy Clin Immunol. 2010;125:676–682.
- Sharma VK, Gupta V, Pathak M, et al. An open-label prospective clinical study to assess the efficacy of increasing levocetirizinedose up to four times in chronic spontaneous urticaria not controlledwith standard dose. J Dermatolog Treat. 2017;28:539–543.
- Godse KV. Ebastine in chronic spontaneous urticaria in higher doses. Indian J Dermatol. 2011;56:597–598.
- Audicana MT, Lecha M, Marquina A, et al. Adouble-blind, randomized, dose-ranging trial in four parallel groups of 10, 20, and 30mg bilastine once daily vs placebo in the symptomatic treatment of chronic idiopathicurticaria (CIU). J Investig Allergol Clin Immunol. 2007;17(Suppl 3):77.
- Weller K, Church MK, Hawro T, et al. Updosing of bilastine is effective in moderate to severe chronic spontaneous urticaria: A real-life study. Allergy 2018;73:2073–2075.
- Hindmarch I, Shamsi Z, Kimber S. An evaluation of the effects of high-dose fexofenadine on the central nervous system: a double-blind, placebo-controlled study in healthy volunteers. Clin Exp Allergy. 2002;32:133–139.
- Siebenhaar F, Degener F, Zuberbier T, et al. High-dose desloratadine decreases wheal volume and improves cold provocation thresholds compared with standard-dose treatment in patients with acquired cold urticaria: a randomized, placebo-controlled, crossover study. J Allergy Clin Immunol. 2009;123:672–679.
- Gillen MS, Miller B, Chaikin P, et al. Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval. Br J Clin Pharmacol. 2001 Aug; 52(2): 201–204.
- Krause K, Spohr A, Zuberbier T, et al. Up-dosing with bilastine results in improved effectiveness in cold contact urticaria. Allergy. 2013;68:921–928.
- Conen S, Theunissen EL, Van Oers AC, et al. Acute and subchronic effects of bilastine (20 and 40 mg) and hydroxyzine (50 mg) on actual driving performance in healthy volunteers. J Psychopharmacol. 2011;25:1517–1523.
- Church MK, Labeaga L. Bilastine: a new H1 -antihistamine with an optimal profile for updosing in urticaria. J Eur Acad Dermatol Venereol. 2017;31:1447–1452.
- Sánchez-Borges M, Caballero-Fonseca F, Capriles-Hulett A. Treatment of recalcitrant chronic urticaria with nonsedating antihistamines: is there evidence for updosing? J Investig Allergol Clin Immunol. 2013;23:141–144.
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- Dubertret L, Zalupca L, Cristoroulo T, et al. Once-daily rupatadine improves the symptoms of chronic idiopathic urticaria: A randomized, double-blind, placebo-controlled study. Eur J Dermatol. 2007;17:223–228.
- Gimenez-Arnau A, Pujol RM, Ianosi S, et al. The Rupatadine Study Group. Rupatadine in the treatment of chronic idiopathic urticaria: A double-blind, randomized, placebo-controlled multicenter study. Allergy. 2007;62:539–546.
- Gimenez-Arnau A, Izquierdo I, Maurer M. The use of a responder analysis to identify clinically meaningful differences in chronic urticaria patients following placebo-controlled treatment with rupatadine 10 and 20 mg. J Eur Acad Dermatol Venereol. 2009;23:1088–1091.
- Abajian M, Curto-Barredo L, Krause K, et al. Rupatadine 20mg and 40mg are Effective in Reducing the Symptoms of Chronic Cold Urticaria. Acta Derm Venereol. 2016;96:56–59.
- Hide M, Suzuki T, Tanaka A, et al. Efficacy of increased dose of rupatadine up to 20 mg on itching in Japanese patients due to chronic spontaneous urticaria, dermatitis, or pruritus: A post hoc analysis of phase III clinical trial. Journal of Cutaneous Immunology and Allergy. 2019;2:128–134.
- Gabrielli S, Le M, Netchiporouk E, et al. Chronic urticaria in children can be controlled effectively with updosing second-generation antihistamines. J Am Acad Dermatol. 2020;82:1535–1537.
- Sarti L, Barni S, Giovannini M, et al. Efficacy and tolerability of the updosing of second-generation non-sedating H1 antihistamines in children with chronic spontaneous urticaria. Pediatr Allergy Immunol. 2021;32:153–160.
- Weller K, Ziege C, Staubach P, et al. H1-Antihistamine Up-Dosing in Chronic Spontaneous Urticaria: Patients’ Perspective of Effectiveness and Side Effects – A Retrospective Survey Study. 2011. PLoS ONE.6(9): e23931.