Background. Dr. Frederic Mohs believed that surgery can spread a melanoma; to prevent this, he applied an inactive black paste vehicle containing the active ingredient 50% zinc chloride solution to melanomas to kill and fix (i.e., preserve) tissue; this is termed fixed-tissue surgery.
J Clin Aesthet Dermatol. 2019;12(1):28–31 by Andrew Duncanson, DO; Michael Kopstein, DO; and Stanley Skopit, DO, MSE, FAOCD, FAAD Drs. Duncanson and Skopit are with the Larkin Community Hospital/LECOM Dermatology Residency Training Program in Miami, Florida. Dr. Kopstein is with the Sky Ridge Medical Center/RVUCOM Internal Medicine Residency Training Program in Lone Tree, Colorado. Funding: No