Dear Colleagues:
Welcome to the December 2017 issue of the Journal of Clinical and Aesthetic Dermatology (JCAD). We start this issue with a study titled “Optimizing Facial Rejuvenation with a Combination of a Novel Topical Serum and Injectable Procedure to Increase Patient Outcomes and Satisfaction.” In this study, Fabi et al assessed overall facial skin quality and patient satisfaction when combining topical treatment with the topical cosmetic serum HA5 following a pre-elected neuromodulator injection treatment to the lateral canthal areas. The authors found that the combination of HA5 with the injectable procedure provided a rapid onset of improvement in fine lines and wrinkles, appearance and texture of skin, and long-term overall improvements in areas of the skin not treated by the injection.
Next, Siegel et al provide the results of their study in the article titled “Three-day Field Treatment with Ingenol Disoxate (LEO 43204) for Actinic Keratosis: A Phase II Trial.” The results show that nine of 63 patients in the face/chest group reported dose-limiting events; zero of 63 patients in the scalp group reported dose-limiting events; and 11 of 62 patients in the trunk/extremities group reported dose-limiting events. The authors concluded that ingenol disoxate is effective in patients with actinic keratosis and that adverse events and local skin reaction profiles are similar to those seen in trials evaluating shorter two-day regimens. They added that their data support the use of ingenol disoxate gel for actinic keratosis field treatment.
Following this, in the article titled “Efficacy and Safety of an Anti-aging Technology for the Treatment of Facial Wrinkles and Skin Moisturization,” Pinsky provides results from a study that evaluated the efficacy of five topical test products, all of which are based on a proprietary anti-aging technology platform, on reducing the appearance of lines and wrinkles, increasing skin moisturization, and reducing transepidermal water loss. Pinsky reports that the facial, eye, and lip creams used in the study were effective in reducing the appearance of both fine and coarse lines and wrinkles. These topical products also dramatically increased moisturization of the skin, and, in the case of the face and eye products, reduced transepidermal water loss.
Next, El-Hoshy present their study titled “Efficacy of Fractional Carbon Dioxide Laser in the Treatment of Mature Burn Scars: A Clinical, Histopathological, and Histochemical Study.” Here, the authors evaluated the efficacy of fractional carbon dioxide laser in the treatment of mature burn scars. The authors report that, after the laser treatment, their patients showed significant reduction in both the Vancouver Scar Scale and Patient and Observer Scar Assessment Scale. Scar relief and pliability were most improved followed by vascularity. Patients also noted a significant change in their scar appearance.
Following this, in the article titled “A Retrospective Analysis of Surveillance Adherence of Patients after Treatment of Primary Cutaneous Melanoma,” Reserva et al identify demographic and clinico-pathologic variables associated with poor adherence to National Comprehensive Cancer Network melanoma surveillance guidelines. The research team found that patients younger than 50 years of age, those lacking health insurance, and those with at least Stage IIB disease are more likely to be poorly adherent to melanoma surveillance.
And finally, in their article titled “Pseudocellulitis Need Not Be Benign: Three Cases of Superficial Migratory Thrombophlebitis (SMT) with ‘Negative’ Venous Duplex Ultrasonography,” Tian et al describe three cases of SMT that were misdiagnosed and admitted for cellulitis after venous duplex scans were interpreted as normal. They note that SMT is a frequently missed sign of malignancy, and in hospital settings, its misdiagnosis as cellulitis has reached up to 28 percent.
We hope you enjoy this issue of JCAD. As always, we welcome your feedback and submissions.
With regards,
James Q. Del Rosso, DO, FAOCD
Editor-in-Chief, Clinical Dermatology
Wm. Philip Werschler, MD, FAAD, FAACS
Editor-in-Chief, Aesthetic Dermatology
Seemal R. Desai, MD, FAAD
Associate Editor