by Philip R. Cohen, MD Dear Editor: I read with interest the recent report by Snyder et al[1] describing melasma associated with the application of a topical estrogen cream. The development of melasma is multifactorial and female sex hormones have been implicated in the pathogenesis of this condition.[2] Estrogen receptor expression is increased in melasma … Continue reading Letter to the Editor: Topical Anti-Estrogen Therapy To Treat Melasma